Fluconazole Therapy

A recent randomized controlled trial in patients with early septic shock suggested that fluconazole offers protection against shock due to bacterial peritonitis. This protection appeared to be unrelated to the antifungal action of the drug. Fluconazole also appeared to have a protective effect in a rat model of peritonitis.

Sepsis is now the tenth most common cause of death in the US , with an average mortality rate for severe sepsis of 29% . The reasons for the high mortality in this condition …